ⓘ HLA-B alleles ..

HLA-B7

HLA-B7 is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products. B7, previously HL-A7, was one of the first HL-A antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.

HLA-B8

HLA-B8 is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-B14

HLA-B14 is a HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B. B14 is a broad antigen composed to two, B64 and B65, split antigens. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens see Table below.

HLA-B18

HLA-B18 is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

HLA-B35

HLA-B35 is an HLA-B serotype. The serotype identifies the more common HLA-B*35 gene products. B35 is one of the largest B serotype groups, it currently has 97 known nucleotide variants and 86 polypeptide isoforms. This variant is particularly susceptible to HIV infection.

HLA-B38

HLA-B38 is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus. B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.

                                     

ⓘ HLA-B alleles

  • HLA - B 15 B 15 is an HLA - B serotype. The serotype identifies the B 15 gene - allele protein products of HLA - B B 15 is a broad antigen can be subdivided into
  • HLA - B 73 B 73 is an HLA - B serotype. The serotype identifies the HLA - B 7301 gene product. Part of B 7301 is similar to the HLA - B 22 family, however part
  • HLA - B 7 B 7 is an HLA - B serotype. The serotype identifies the more common HLA - B 07 gene products. For terminology help see: HLA - serotype tutorial B 7
  • HLA - B 57 B 57 is an HLA - B serotype. B 57 is a split antigen from the B 17 broad antigen, the sister serotype B 58. The serotype identifies the more common
  • at least 28 very similar alleles are subtypes of HLA - B 27. These subtypes are designated as HLA - B 2701 to HLA - B 2728. The HLA - B gene is located on the short
  • HLA - B 38 B 38 is an HLA - B serotype. The serotype identifies the B 38 allele products of the HLA - B gene - locus. B 38 is a split antigen of the broad antigen
  • HLA - B 58 B 58 is an HLA - B serotype. B 58 is a split antigen from the B 17 broad antigen, the sister serotype B 57. The serotype identifies the more common
  • HLA - B 13 B 13 is an HLA - B serotype. The serotype identifies the more common HLA - B 13 gene products. For terminology help see: HLA - serotype tutorial Marsh
  • HLA - B 8 B 8 is an HLA - B serotype. The serotype identifies the HLA - B 08 gene products. For terminology help see: HLA - serotype tutorial HLA - B 8, previously