ⓘ Human MHC haplogroups ..

HLA A1-B8 haplotype

HLA A1-B8 is a multigene haplotype that covers the MHC Class I region of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are generally the result of identity by descent from a common ancestor. Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations. The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA A *01:01: Cw *07:01: B *08:01 However, ...

HLA B7-DR15-DQ6

HLA B7-DR15-DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles, common multigene haplotypes are generally the result of descent by common ancestry. Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations. HLA B7-DR15-DQ6 is a representationby serotype of a common HLA haplotype found in Western Eurasia. The haplotype can be written in an extended form covering the major h ...

HLA DR3-DQ2

HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming maj ...

                                     

ⓘ Human MHC haplogroups

  • The human leukocyte antigen HLA system or complex is a gene complex encoding the major histocompatibility complex MHC proteins in humans These cell - surface
  • and HLA - DPB1, that are found in the MHC Class II or HLA - D region in the Human Leukocyte Antigen complex on human chromosome 6 see protein boxes on right
  • COX, Super B8, ancestral MHC 8.1 or 8.1 ancestral haplotype is a multigene haplotype that covers a majority of the human major histocompatibility complex
  • A 01: 01 - C 07: 01 - B 08: 01 is a multigene haplotype that covers the MHC Class I region of the human major histocompatibility complex on chromosome 6. A multigene
  • HLA B7 - DR15 - DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is
  • M, Papassavas A, Schipper R, Doxiadis I, Stavropoulos - Giokas C 2000 MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks