ⓘ CEPP is an acronym for the name of a chemotherapy regimen that is intended for treatment of aggressive non-Hodgkin lymphomas. Unlike CHOP, this chemotherapy reg ..

                                     

ⓘ CEPP

CEPP is an acronym for the name of a chemotherapy regimen that is intended for treatment of aggressive non-Hodgkin lymphomas. Unlike CHOP, this chemotherapy regimen does not contain doxorubicin or any other anthracycline. Thus, it can be used in patients with severe cardiovascular diseases and contraindications for doxorubicin-containing regimens. There are 2 modifications of CEPP - with the addition of bleomycin, called CEPP, and without bleomycin - ordinary CEPP.

This regimen also does not contain vincristine and can be used in patients with neuropathy.

In combination with anti-CD20, monoclonal, antibody, and rituximab. this regimen is called R-CEPPB.

-CEPPB regimen consists of:

  • C yclophosphamide - an alkylating antineoplastic agent;
  • P rednisone or P rednisolone - a glucocorticoid hormone that has the ability to cause apoptosis and lysis of lymphocytes, either normal or malignant;
  • E toposide - a topoisomerase inhibitor from the epipodophyllotoxin group;
  • R ituximab - a monoclonal antibody that is able to kill CD20-positive B cells, either normal or malignant;
  • P rocarbazine - an alkylating antineoplastic agent;
  • B leomycin - an antitumor antibiotic.
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