ⓘ HLA-B51 is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. B51 is a split antigen of the broad antigen B5, and is a sister se ..

                                     

ⓘ HLA-B51

HLA-B51 is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52. There are many alleles within the B*51 allele group. B51 is associated with several diseases, including Behçets disease.

                                     

1. Alleles

There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B*5101 is the most common, but others have a large regional abundance.

                                     

2. Disease associations

By serotype

Bw51 was associated with Behçets disease, in endemic versus epidemic mucocutaneous lymph node syndrome, susceptibility to the virus that causes German measles infection.

                                     

3. In Behçets disease

Behçets disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body. Several alleles of B51 are found in disease, and linkage to markers, D6S285, in the HLA locus was strong (P