ⓘ HLA-B7 is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products. B7, previously HL-A7, was one of the first HL-A antigens recognized ..

                                     

ⓘ HLA-B7

HLA-B7 is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products. B7, previously HL-A7, was one of the first HL-A antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.

                                     

1.1. In disease Sarcoidosis

A relationship between HLA-B7 and sarcoidosis has been known for 30+ years. However the association is weak and has not been reproducible in all studies. A common serologically defined haplotype in Europeans is HLA A3-Cw7-B7-DR15-DQ6.2 which is composed of alleles A*0301:Cw*0701:B*0702:DRB1*1501:DQA1*0102:DQB1*0602. In persistent sarcoidosis this haplotype was found to be increased in sarcoidosis, and further study eliminated risk contributed by A3-Cw7 and DQ6.2 indicating B7-DR15 haplotype contains risk of disease OR = 2.5. The region of chromosome 6 contains nearly on million nucleotides so that these genes, or a closely linked gene could be involved in disease.

                                     

1.2. In disease Juvenile Spondylarthropathies

In Croatian children, two HLA-B27 alleles were found associated with disease, B*2702, B*2705. The study showed also B*0702 in cooperation with B*27, the HLA-B*07/B*27 combination with D6S273-134 genomic marker allele and was found not to be the result of linkage disequilibrium. B*2705 was found to be dominant allele associated.

                                     

1.3. In disease Haemochromatosis

The HFE gene responsible for haemochromatosis is distal on chromosome 6 from HLA-A and more so from HLA-B, the distance suffices 3 million nucleotides to allow equilibration of the loci. Nonetheless, a linkage has been found between A3-B7 haplotype and haemochromatosis. The region is almost 1.4 million nucleotides in length and contains many other genes that could be involved. A more recent study looked at a number of linked gene-alleles and found I82-2:D6S265-1:HLA-A3:D6S128-2:HLA-F1:D6S105-8 was constantly associated while B7 appeared beyond the haplotype linked to disease.

                                     
  • HLA B7 - DR15 - DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is
  • and HLA B7 - DR15 - DQ6 haplotypes. The class I region of these supertype is HLA A1 - B 8 haplotype, HLA A3 - B7 HLA - A2 - B7 and HLA A24 - B7 Arce - Gomez B Jones
  • kite B7 protein a protein in the immune system HLA - B7 an HLA - B serotype Vitamin B7 another name for biotin a subclass of B - class stars B7 a diesel
  • critical role in the immune system. HLA - B is part of a family of genes called the human leukocyte antigen HLA complex. The HLA complex helps the immune system
  • Ways JP, Lawlor DA, Wan AM, Parham P 1987 A transposable epitope of HLA - B7 B 40 molecules Immunogenetics. 25 5 323 8. doi: 10.1007 BF00404425. PMID 2437025
  • to HLA - B7 in the alpha 1 - helix J. Immunol. 148 4 1155 62. PMID 1737933. Marsh, S. G. Albert, E. D. Bodmer, W. F. Bontrop, R. E. Dupont, B Erlich
  • Ways JP, Lawlor DA, Wan AM, Parham P 1987 A transposable epitope of HLA - B7 B 40 molecules Immunogenetics. 25 5 323 8. doi: 10.1007 BF00404425. PMID 2437025
  • HLA - B 15 B 15 is an HLA - B serotype. The serotype identifies the B 15 gene - allele protein products of HLA - B B 15 is a broad antigen can be subdivided into
  • HLA - B 57 B 57 is an HLA - B serotype. B 57 is a split antigen from the B 17 broad antigen, the sister serotype B 58. The serotype identifies the more common
  • HLA - C alleles that are Class - I MHC receptors. HLA - C, localized proximal to the HLA - B locus, is located on the distal end of the HLA region. Most HLA - C: B