ⓘ Phospho-N-acetylmuramoyl-pentapeptide-transferase. In enzymology, a phospho-N-acetylmuramoyl-pentapeptide-transferase is an enzyme that catalyzes the chemical r ..

                                     

ⓘ Phospho-N-acetylmuramoyl-pentapeptide-transferase

In enzymology, a phospho-N-acetylmuramoyl-pentapeptide-transferase is an enzyme that catalyzes the chemical reaction

UDP-Mur 2 Acoyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala + undecaprenyl phosphate ⇌ {\displaystyle \rightleftharpoons } UMP + Mur 2 Acoyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala- diphosphoundecaprenol

Thus, the two substrates of this enzyme are UDP-Mur2Acoyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala and undecaprenyl phosphate, whereas its 3 products are UMP, Mur2Acoyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala-, and diphosphoundecaprenol. This enzyme participates in peptidoglycan biosynthesis. It can be expressed efficiently by cell-free protein expression system.

                                     

1. Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is UDP-MurAcoyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala:undecaprenyl-phos phate phospho-N-acetylmuramoyl-pentapeptide-transferase. Other names in common use include MraY transferase, UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid, alcohol transferase, UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate, transferase, phospho-N-acetylmuramoyl pentapeptide translocase, phospho-MurNAc-pentapeptide transferase, phospho-NAc-muramoyl-pentapeptide translocase UMP, phosphoacetylmuramoylpentapeptide translocase, and phosphoacetylmuramoylpentapeptidetransferase.

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