ⓘ Hydroxyethylthiazole kinase. In enzymology, a hydroxyethylthiazole kinase is an enzyme that catalyzes the chemical reaction ATP + 4-methyl-5-2-hydroxyethylthiaz ..

                                     

ⓘ Hydroxyethylthiazole kinase

In enzymology, a hydroxyethylthiazole kinase is an enzyme that catalyzes the chemical reaction

ATP + 4-methyl-5-2-hydroxyethylthiazole ⇌ {\displaystyle \rightleftharpoons } ADP + 4-methyl-5-2-phosphonooxyethylthiazole

Thus, the two substrates of this enzyme are ATP and 4-methyl-5-2-hydroxyethylthiazole, whereas its two products are ADP and 4-methyl-5-2-phosphonooxyethylthiazole.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups phosphotransferases with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-methyl-5-2-hydroxyethylthiazole 2-phosphotransferase. Other names in common use include hydroxyethylthiazole kinase phosphorylating, and 4-methyl-5-beta-hydroxyethylthiazole kinase. This enzyme participates in thiamine metabolism. Thiamine pyrophosphate TPP, a required cofactor for many enzymes in the cell, is synthesised de novo in Salmonella typhimurium.

In Saccharomyces cerevisiae, hydroxyethylthiazole kinase expression is regulated at the mRNA level by intracellular thiamin pyrophosphate.

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