ⓘ Neolactotetraosylceramide alpha-2.3-sialyltransferase. In enzymology, a neolactotetraosylceramide alpha-2.3-sialyltransferase is an enzyme that catalyzes the ch ..

                                     

ⓘ Neolactotetraosylceramide alpha-2.3-sialyltransferase

In enzymology, a neolactotetraosylceramide alpha-2.3-sialyltransferase is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1.4-N-acetyl-beta-D-glucosaminyl-1.3-beta-D- galactosyl-1.4-D-glucosylceramide ⇌ {\displaystyle \rightleftharpoons } CMP + alpha-N-acetylneuraminyl-2.3-beta-D-galactosyl-1.4-N-acetyl-beta-D- glucosaminyl-1.3-beta-D-galactosyl-1.4-D-glucosylceramide

The 3 substrates of this enzyme are CMP-N-acetylneuraminate, beta-D-galactosyl-1.4-N-acetyl-beta-D-glucosaminyl-1.3-beta-D-, and galactosyl-1.4-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2.3-beta-D-galactosyl-1.4-N-acetyl-beta-D-, and glucosaminyl-1.3-beta-D-galactosyl-1.4-D-glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2.3-sialyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-neolactotetraosylceramide, sialyltransferase, sialyltransferase 3, and SAT-3. This enzyme participates in glycosphingolipid biosynthesis - neo-lactoseries and glycan structures - biosynthesis 2.

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