ⓘ Lactosylceramide alpha-2.3-sialyltransferase. In enzymology, a lactosylceramide alpha-2.3-sialyltransferase is an enzyme that catalyzes the chemical reaction CM ..

                                     

ⓘ Lactosylceramide alpha-2.3-sialyltransferase

In enzymology, a lactosylceramide alpha-2.3-sialyltransferase is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1.4-beta-D-glucosylceramide ⇌ {\displaystyle \rightleftharpoons } CMP + alpha-N-acetylneuraminyl-2.3-beta-D-galactosyl-1.4-beta-D- glucosylceramide

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1.4-beta-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2.3-beta-D-galactosyl-1.4-beta-D-, and glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:lactosylceramide alpha-2.3-N-acetylneuraminyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-lactosylceramide alpha2.3-, sialyltransferase, CMP-acetylneuraminate-lactosylceramide-sialyltransferase, CMP-acetylneuraminic acid:lactosylceramide sialyltransferase, CMP-sialic acid:lactosylceramide-sialyltransferase, cytidine monophosphoacetylneuraminate-lactosylceramide, sialyltransferase, ganglioside GM3 synthetase, GM3 synthase, GM3 synthetase, and SAT 1. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.

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