ⓘ N-acetyl-gamma-glutamyl-phosphate reductase. In enzymology, a N-acetyl-gamma-glutamyl-phosphate reductase is an enzyme that catalyzes the chemical reaction N-ac ..

                                     

ⓘ N-acetyl-gamma-glutamyl-phosphate reductase

In enzymology, a N-acetyl-gamma-glutamyl-phosphate reductase is an enzyme that catalyzes the chemical reaction

N-acetyl-L-glutamate 5-semialdehyde + NADP + + phosphate ⇌ {\displaystyle \rightleftharpoons } N-acetyl-L-glutamyl 5-phosphate + NADPH + H +

The 3 substrates of this enzyme are N-acetyl-L-glutamate 5-semialdehyde, NADP +, and phosphate, whereas its 3 products are N-acetyl-L-glutamyl 5-phosphate, NADPH, and H +.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase phosphorylating. Other names in common use include reductase, acetyl-gamma-glutamyl phosphate, N-acetylglutamate 5-semialdehyde dehydrogenase, N-acetylglutamic gamma-semialdehyde dehydrogenase, N-acetyl-L-glutamate gamma-semialdehyde:NADP+ oxidoreductase, and phosphorylating. This enzyme participates in urea cycle and metabolism of amino groups.

                                     

1. Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1VKN, 2CVO, 2G17, 2I3A, 2I3G, 2NQT, 2OZP, and 2Q49.

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