ⓘ 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase. In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase is an enzyme that catalyzes the chem ..

                                     

ⓘ 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase is an enzyme that catalyzes the chemical reaction

7alpha-hydroxycholest-4-en-3-one + NADPH + H + + O 2 ⇌ {\displaystyle \rightleftharpoons } 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP + + H 2 O

The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one.

This enzymatic activity is performed by CYP8B1.

Other names used include 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, sterol 12alpha-hydroxylase ambiguous, and HCO 12alpha-hydroxylase. This enzyme participates in ppar signaling pathway.

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