ⓘ 24-hydroxycholesterol 7alpha-hydroxylase. In enzymology, a 24-hydroxycholesterol 7alpha-hydroxylase is an enzyme that catalyzes the chemical reaction 24R-choles ..

                                     

ⓘ 24-hydroxycholesterol 7alpha-hydroxylase

In enzymology, a 24-hydroxycholesterol 7alpha-hydroxylase is an enzyme that catalyzes the chemical reaction

24R-cholest-5-ene-3beta,24-diol + NADPH + H + + O 2 ⇌ {\displaystyle \rightleftharpoons } 24R-cholest-5-ene-3beta,7alpha,24-triol + NADP + + H 2 O

The 4 substrates of this enzyme are 24R-cholest-5-ene-3beta,24-diol, NADPH, H +, and O 2, whereas its 3 products are 24R-cholest-5-ene-3beta,7alpha,24-triol, NADP +, and H 2 O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 24R-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase 7alpha-hydroxylating. Other names in common use include 24-hydroxycholesterol 7alpha-monooxygenase, CYP39A1, and CYP39A1 oxysterol 7alpha-hydroxylase.

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