ⓘ 15-hydroxyprostaglandin-I dehydrogenase, NADP+. In enzymology, a 15-hydroxyprostaglandin-I dehydrogenase is an enzyme that catalyzes the chemical reaction 5Z,13 ..

                                     

ⓘ 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

In enzymology, a 15-hydroxyprostaglandin-I dehydrogenase is an enzyme that catalyzes the chemical reaction

5Z,13E-15S-6.9alpha-epoxy-11alpha,15-dihydroxyprosta-5.13- dienoate + NADP + ⇌ {\displaystyle \rightleftharpoons } 5Z,13E-6.9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5.13-dienoate + NADPH + H +

The 3 substrates of this enzyme are 5Z,13E-15S-6.9alpha-epoxy-11alpha,15-dihydroxyprosta-5.13-, dienoate, and NADP +, whereas its 3 products are 5Z,13E-6.9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5.13-dienoate, NADPH, and H +.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is 5Z,13E-15S-6.9alpha-epoxy-11alpha,15-dihydroxyprosta-5.13-dienoa te:NADP + 15-oxidoreductase. Other names in common use include prostacyclin dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase, NADP + -linked 15-hydroxyprostaglandin prostacyclin dehydrogenase, NADP + -dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin-I dehydrogenase NADP +.

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