ⓘ 15-hydroxyicosatetraenoate dehydrogenase. In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase is an enzyme that catalyzes the chemical reaction 15S-15-hyd ..

                                     

ⓘ 15-hydroxyicosatetraenoate dehydrogenase

In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase is an enzyme that catalyzes the chemical reaction

15S-15-hydroxy-5.8.11-cis-13-trans-icosatetraenoate + NADP+ ⇌ {\displaystyle \rightleftharpoons } 15-oxo-5.8.11-cis-13-trans-icosatetraenoate + NADPH + H +

The 3 substrates of this enzyme are 15-Hydroxyicosatetraenoic acid i.e. 15S-15-hydroxy-5.8.11-cis-13-trans-icosatetraenoate), NAD +, and NADP +, whereas its 4 products are 15-oxo-5.8.11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H +.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is 15S-15-hydroxy-5.8.11-cis-13-trans-icosatetraenoate:NADP + 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.

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