ⓘ Sterol-4alpha-carboxylate 3-dehydrogenase, decarboxylating. In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase is an enzyme that catalyzes the chemical ..

                                     

ⓘ Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

In enzymology, a sterol-4alpha-carboxylate 3-dehydrogenase is an enzyme that catalyzes the chemical reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP + ⇌ {\displaystyle \rightleftharpoons } 4alpha-methyl-5alpha-cholest-7-en-3-one + CO 2 + NADPH

The 3 substrates of this enzyme are 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate, NAD +, and NADP +, whereas its 4 products are 4alpha-methyl-5alpha-cholest-7-en-3-one, CO 2, NADH, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NADP + 3-oxidoreductase decarboxylating. Other names in common use include 3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase, decarboxylating, 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, and sterol 4alpha-carboxylic decarboxylase. This enzyme participates in biosynthesis of steroids.

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