ⓘ 4-Hydroxybutyrate dehydrogenase. In enzymology, a 4-hydroxybutyrate dehydrogenase is an enzyme that catalyzes the chemical reaction 4-hydroxybutanoate + NAD + ⇌ ..

                                     

ⓘ 4-Hydroxybutyrate dehydrogenase

In enzymology, a 4-hydroxybutyrate dehydrogenase is an enzyme that catalyzes the chemical reaction

4-hydroxybutanoate + NAD + ⇌ {\displaystyle \rightleftharpoons } succinate semialdehyde + NADH + H +

The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD +, whereas its 3 products are succinate semialdehyde, NADH, and H +.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is 4-hydroxybutanoate:NAD + oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid.

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